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Silda 50

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Indications:

Treatment of erectile dysfunction, treatment of pulmonary arterial hypertension to improve exercise ability.

Contraindications:

Hypersensitivity. Patients concurrently using nitric oxide donors, organic nitrates or nitrites in any form either regularly or intermittently. Women, childn <18 yr.

Adverse reactions:

Headache, vasodilation, dizziness, abnormal vision, chromatopsia, palpitation, rhinitis, dyspepsia. Hypersensitivity reaction, seizure, seizure recurrence, tachycardia, hypotension, syncope, epistaxis, vomiting, eye pain, red eyes, prolonged erection &/or priapism.

Interactions:

CYP3A4 inhibitors (eg ketoconazole, itraconazole, erythromycin, cimetidine, saquinavir), ritonavir, α-blockers (doxazosin). Potentiates hypotensive effect of acute & chronic nitrates.

Warnings:

Men for whom sexual activity is inadvisable. Medical history & physical exam should be undertaken to diagnose erectile dysfunction & determine potential underlying causes prior to treatment. Patient w/ increased susceptibility to vasodilators (eg w/ left ventricular outflow obstruction, aortic stenosis, hypertrophic obstructive cardiomyopathy, multiple system atrophy). Severe CV events, aortic stenosis, hypertrophic obstructive cardiomyopathy. Retinitis pigmentosa; bleeding disorders or active peptic ulceration. Anatomical deformation of the penis or in patients w/ conditions predisposing to priapism. Combination w/ other treatments for erectile dysfunction, α-blockers.

Form:

COATED TABLET

Dosage and Administration

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