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Longacef

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Indications:

Treatment of uncomplicated UTIs, otitis media, pharyngitis, tonsillitis, acute bronchitis, acute exacerbations of chronic bronchitis, and uncomplicated gonorrhea caused by susceptible strains of specific organisms.

Contraindications:

Allergy to cephalosporin group of antibiotics

Adverse reactions:

CNS Dizziness, headache, seizure (less than 2%). Dermatologic Erythema multiforme, facial edema, pruritus, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria (less than 2%). GI Diarrhea (16%); nausea (7%); loose or frequent stools (6%); flatulence (4%); abdominal pain, dyspepsia (3%); vomiting (less than 2%); pseudomembranous colitis. Genitourinary Acute renal failure, candidiasis, genital pruritus, transient elevations in BUN or creatinine, vaginitis (less than 2%). Hematologic-Lymphatic Eosinophilia, leukopenia, neutropenia, prolongation in PT, transient thrombocytopenia (less than 2%); agranulocytosis, pancytopenia. Hepatic Hepatitis, jaundice, transient elevations in alkaline phosphatase, ALT, and AST (less than 2%). Hypersensitivity Anaphylactic/anaphylactoid reactions (including shock and death), angioedema, drug fever, serum sickness–like reactions (less than 2%). Lab Tests Hyperbilirubinemia (less than 2%).

Interactions:

Carbamazepine Plasma concentrations may be elevated by cefixime, increasing the risk of adverse reactions. Warfarin Increased PT, with and without bleeding, may occur. Laboratory Test Interactions May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets, but not with enzyme-based tests (eg, Clinistix , Tes-tape ); false-positive test results for ketones in the urine may occur with tests using nitroprusside but not nitroferricyanide; false-positive direct Coombs test.

Warnings:

Monitor Monitor PT and patient’s response to therapy. Adverse reactions Monitor patient for GI, CNS, general body adverse reactions, and signs of superinfection. Pregnancy Category B . Lactation Undetermined. Children Safety and efficacy not established in children younger than 6 mo of age. Hypersensitivity If administered to penicillin-allergic patients, use with caution because cross-sensitivity has been documented and may occur in up to 10% of patients with penicillin allergy. Renal Function Use with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required. Ensure that reduced dose is administered to patient with renal function impairment (CrCl less than 60 mL/min) following manufacturer’s guidelines. Superinfection May result in bacterial or fungal overgrowth of nonsusceptible microorganisms. GI disease Use with caution, especially for colitis. Prothrombin activity A fall in prothrombin activity may occur; patients at risk include patients with renal or hepatic function impairment, poor nutritional status, patients receiving protracted antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Pseudomembranous colitis Consider possibility if diarrhea develops.

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