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Treatment of infections of respiratory tract, urinary tract, skin and skin structures; treatment of STDs caused by susceptible strains of specific microorganisms.


Hypersensitivity to cephalosporins.

Adverse reactions:

GI Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. Genitourinary Pyuria; renal function impairment; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. Hematologic Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. Hepatic Hepatic function impairment; abnormal LFT results. Miscellaneous Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; serum sickness–like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); candidal overgrowth.


Probenecid Inhibition of renal excretion of cefpodoxime. Laboratory Test Interactions May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-tape ); false-positive test results for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs test result in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values.


Monitor Response to therapy Monitor patient’s response to therapy. Notify health care provider if infection does not appear to improve or worsens. Adverse reactions Monitor patient for GI, DERM, and general body adverse reactions, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping. Pregnancy Category B . Lactation Excreted in breast milk. Children Consider benefits relative to risks. Safety and efficacy in children younger than 6 mo of age not established. Hypersensitivity Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity. Renal Function Use drug with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required. Superinfection May result in bacterial or fungal overgrowth of nonsusceptible microorganisms. Pseudomembranous colitis Consider in patients in whom diarrhea develops.



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