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Reactine Duo

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Indications:

Relief of nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis.

Contraindications:

Narrow-angle glaucoma; urinary retention; severe hypertension; severe coronary artery disease; patients receiving MAOIs or within 14 days of stopping such treatment; hypersensitivity to any component of the product, adrenergic agents, or other drugs of similar chemical structure; manifestations of patient idiosyncrasy to adrenergic agents, including arrhythmias, dizziness, insomnia, tremor, or weakness.

Adverse reactions:

CNS Insomnia (4%); fatigue, somnolence (2%); dizziness (1%). EENT Pharyngitis (2%); epistaxis (1%). GI Dry mouth (4%). Respiratory Sinusitis (1%). Miscellaneous Accidental injury (1%).

Interactions:

Antihypertensive agents that interfere with sympathetic activity (eg, mecamylamine, methyldopa, reserpine) Antihypertensive effects of these agents may be reduced. Digitalis Increased ectopic pacemaker activity. MAOIs (eg, phenelzine) Coadministration is contraindicated with pseudoephedrine and for 14 days after stopping the MAOI. Sympathomimetic amines Additive or potentiated effects on the CV system. Laboratory Test Interactions Positive reactions to skin tests may be prevented or diminished.

Warnings:

Pregnancy Category C . Lactation Both ingredients are excreted in breast milk. Children Safety and efficacy not established in children younger than 12 yr of age. Elderly Use with caution, usually starting at the low end of the dosage range, because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy. Special Risk Patients Use with caution in patients with diabetes mellitus, hypertension, hyperthyroidism, increased IOP, ischemic heart disease, prostatic hypertrophy, or renal function impairment. Cognitive and motor impairment Caution patients about operating potentially hazardous machinery (eg, driving) until they know whether the drug impairs their ability. Avoid use of alcohol.

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