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Topramine

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Info

Indications:

Depression Nocturnal enuresis

Contraindications:

Post MI, heart block/arrhythmias; mania; porphyria; severe hepatic impairment.

Adverse reactions:

Sinus tachycardia, AV/bundle-branch block, postural hypotension, dry mouth, wt loss/gain, constipation, urinary hesitancy/retention, impotence; blurring of vision, exacerbation of glaucoma, liver dysfunction, tremors. Potentially Fatal: Rarely, agranulocytosis.

Interactions:

quinidine, cimetidine, SSRIs, propafenone, flecainide barbiturates, phenytoin altretamine Potentially Fatal: Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 wk.

Warnings:

Epilepsy; children, elderly, pregnancy and lactation; cardiac disease; DM; prostatic hyperplasia; angle-closure glaucoma; phaeochromocytoma. Monitor for increased suicidality during early treatment. Withdraw gradually.

Form:

TABLET

Dosage and Administration

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