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Noliprel

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Indications:

Hypertension

Contraindications:

Bilateral renal artery stenosis or single functioning kidney, severe renal failure (CrCl <30 mL/min), dialysis patients, hepatic encephalopathy, severe hepatic impairment, hyperkalaemia or hypokalaemia, untreated decompensated cardiac insufficiency. Avoid combinations w/ K-sparing diuretics, K salts, lithium & non-antiarrhythmic drugs causing torsades de pointes. Previous history of angioneurotic oedema linked to treatment w/ ACE inhibitor; hereditary or idiopathic angioneurotic oedema. Pregnancy & lactation.

Adverse reactions:

Headache, asthenia, dizziness, mood &/or sleep disturbances, cramps, hypotension, rash, GI disturbances, slight reversible increase in urea & plasma creatinine, hypokalaemia, hyponatraemia w/ hypovolaemia, raised uric acid & blood glucose levels.

Interactions:

Lithium, insulin, sulfonylureas, baclofen, NSAIDs, high dose salicylates, tricyclic antidepressants, neuroleptics, corticosteroids, tetracosactide, K-sparing diuretics, K salts, K-lowering drugs, anaesth, allopurinol, immunosuppressants, cardiac glycosides, procainamide & other drugs which cause torsades de pointes, antihypertensive drugs, metformin, Ca salts, cyclosporin, iodinated contrast media.

Warnings:

Renal insufficiency esp when associated w/ systemic autoimmune collagen vascular diseases eg SLE or scleroderma. Concomitant treatment w/ immunosuppressants or treatment causing leukopenia. Marked Na & water depletion, hypotension, CHF, cirrhosis w/ oedema & ascites, ischaemic heart disease, cerebral circulatory insufficiency, severe cardiac insufficiency (grade IV) or IDDM patients. Monitor serum K regularly. Surgery. Elderly. May impair ability to drive or operate machinery.

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