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Luai Al Bakour
El Temamy Pharmacy
Akoni Hijyen Teknolojileri Sanayi ve Dış Ticaret LTD. ŞTİ
Britton Chance Center for Biomedical Photonics
Arabian Trade Center - ATC
Medical Facility (32206):
Legality International. (Pvt.) Ltd.
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Drug for the symptomatic treatment of acute and chronic stress, excitement, and anxiety.
Do not take: - If you are hypersensitive (allergic) to Medazepam, other benzodiazepines or any of the excipients - With a history of addictive disorders (alcohol, drugs, drugs) - For certain types of severe, pathological muscle weakness (myasthenia gravis)
Nervous system disorders: Common: Undesirable strong sedative on the day, fatigue (sleepiness, fatigue, dizziness, increased reaction time), dizziness, gait and movement disorders (ataxia), headache, confusion, temporary memory loss after taking Medazepam (anterograde amnesia). Not known: a high dosage and prolonged use reversible disorders, such as slowed or slurred speech (articulation disorder), movement and gait unsteadiness. On the morning after the evening administration may affect over effects in the form of residual fatigue and impaired concentration responsiveness. Because of the marked effect of the drug is particularly muscle relaxants in the elderly care (fall risk) offered. Gastrointestinal disorders: Rare: gastrointestinal disturbances (nausea, vomiting, abdominal pain, constipation, diarrhea), dry mouth. Diseases of the liver and gall bladder: Rare: jaundice. Renal and urinary disorders: Rare: urinary retention. Respiratory, thoracic and mediastinal disorders: Rare: laryngospasm (Glottisspasmen), respiratory loss (respiratory depression). The respiratory depressant effects may be during a breath through narrowed airways (airway obstruction) and are amplified in patients with brain damage in appearance. This is important particularly when co-administered with other drugs acting on the brain. General disorders: Rare: chest pain. Vascular disorders: Rare: hypotension. Heart disease: Rare: slowing of heart rate (bradycardia). Psychiatric disorders: Rare: depression (depression), in patients with pre-existing depressive symptoms, the disease can be enhanced. Not known: sensory disturbances (hallucinations), Reverse action ("paradoxical" reactions), such as acute agitation, anxiety, suicidal tendencies (suicidal tendencies), sleep disorders, temper tantrums, increased muscle spasms. The occurrence of these side effects, treatment should be stopped. Reproductive system and breast disorders: Rare: decrease of sexual need, disorders of menstruation in women. Metabolism and nutrition disorders: Rare: increased appetite. Skin and subcutaneous tissue disorders: Rare: allergic skin disorders (such as itching, skin redness, skin rash). Eye disorders: Not known: In high doses and prolonged use temporary disturbances such as blurred vision (Double vision, blurred vision, nystagmus). Side effects are generally returned to dose reduction and can usually avoid by careful adjustment of the individual daily doses. For prolonged or repeated use can decrease the effect (tolerance development) come. By abrupt discontinuation of the drug after prolonged daily use, insomnia and increased dream can occur after about 2-4 days. Anxiety, tension and excitement and anxiety states may appear once again. The appearance can manifest itself in trembling and sweating and increase up to threatening physical and psychological reactions as symptomatic psychosis or seizures. Therefore, the treatment must be stopped gradually.
Concurrent use of other psychotropic drugs to treat mental and emotional disorders, sleeping pills, sometimes even pain relievers, anesthetics or antihistamines may result in mutual reinforcement effects. The effect of drugs, which reduce the muscle tension (muscle relaxants), can be strengthened. Concomitant administration of cimetidine or omeprazole or disulfiram can strengthen and extend the effect of Medazepam. In smokers, the elimination of Medazepam is accelerated. Theophylline causes Medazepam enhancement. Medazepam inhibits the effect of levodopa. In rare cases, the breakdown of phenytoin by Medazepam is inhibited which may lead to amplified effect. Phenobarbital and phenytoin may accelerate the decomposition of Medazepam. In patients who are chronically treated with other drugs, such as centrally acting antihypertensive agents, beta-blockers, antidiabetics , contraceptives ("the pill"), anticoagulants and cardio-active glycosides the nature and extent of interactions are not predictable. Therefore, concomitant use of the drug, especially at the beginning of treatment, should be avoided. The attending physician should clarify before the administration of Medazepam whether there are appropriate treatment duration. Due to slower elimination of Medazepam from the body, there would be possible interactions even after cessation of treatment. Intake together with food and drink: During treatment alcohol should be avoided.
Alcohol can increase or alter the effect of Medazepam unforeseeable way, and therefore its consumption should be avoided during treatment. Pregnancy Use during pregnancy only in exceptional cases, be used strictly on an individual basis. Medazepam use in late Pregnancy may emerge withdrawal symptoms in newborns and can cause addiction and dependence as a result. larger doses before or during birth can cause the infant a low body temperature, low blood pressure, respiratory depression and poor feeding (known as "floppy infant syndrome"). Lactation: Breastfeeding should not be taken as the medazepam and its metabolites pass into breast milk. If the application is absolutely necessary in this case, the infant should be separated.
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Dr. Samer Al-Jneidy
Dr . Dirar Abboud
Dr. Faisal Dibsi
Dr. Tahsin Martini
Samir Moussa M.D.
Dr. Talal Sabouni
Dr. Hani Najjar
Yaser Habrawi , F.R.C.S.Ed