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Indications:

Medroxyprogesterone is a progestin (a form of progesterone), a female hormone that helps regulate ovulation (the release of an egg from an ovary) and menstrual periods. Medroxyprogesterone is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Medroxyprogesterone is also used to decrease the risk of endometrial hyperplasia (a condition that may lead to uterine cancer) while taking estrogens. Medroxyprogesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Contraindications:

You should not use this medication if you are allergic to medroxyprogesterone.

Adverse reactions:

Get emergency medical help if you have any of these signs of an allergic reaction to medroxyprogesterone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; chest pain, sudden cough, wheezing, rapid breathing, fast heart rate; pain or swelling in one or both legs; chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; vaginal bleeding if you have already gone through menopause; feeling like you might pass out; a breast lump; symptoms of depression (sleep problems, dizziness, mood changes, headache); fever; jaundice (yellowing of the skin or eyes); or swelling in your hands, ankles, or feet. Less serious medroxyprogesterone side effects may include: spotting or breakthrough bleeding; changes in your menstrual periods; vaginal itching or discharge; breast tenderness or discharge; mild itching or skin rash; increased acne, hair growth, loss of scalp hair; sleep problems (insomnia); changes in appetite or weight, mild stomach pain, bloating, nausea; or skin color changes.

Interactions:

There may be other drugs that can interact with medroxyprogesterone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Warnings:

You should not use medroxyprogesterone if you are pregnant, or if you have liver disease, a hormone-related cancer such as breast or uterine cancer, a history of stroke or blood clot, or abnormal vaginal bleeding that has not been checked by a doctor. Medroxyprogesterone will not prevent heart disease, breast cancer, or dementia, and may actually increase the risk of developing these conditions in post-menopausal women. Medroxyprogesterone may also increase the risk of uterine or ovarian cancer in some women. Long-term treatment with estrogens and progestins (such as medroxyprogesterone) may also increase your risk of heart attack, blood clot, or stroke. Talk to your doctor about your specific risks and benefits of taking this medication, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. FDA pregnancy category X. Medroxyprogesterone can cause birth defects. Do not use if this medication you are pregnant. Tell your doctor right away if you become pregnant during treatment. You should not use this medication if you are allergic to medroxyprogesterone, or if you have: abnormal vaginal bleeding that has not been diagnosed; a hormone-related cancer such as breast or uterine cancer; liver disease; or a history of stroke or blood clot. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take medroxyprogesterone: heart disease, congestive heart failure, recent stroke or heart attack high blood pressure; high cholesterol or triglycerides; low levels of calcium in your blood; severe pelvic pain; recent miscarriage or abortion; epilepsy; asthma; migraine headaches; a thyroid disorder; kidney disease, diabetes; or lupus. Medroxyprogesterone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Medroxyprogesterone will not prevent heart disease, breast cancer, or dementia, and may actually increase the risk of developing these conditions in post-menopausal women. Medroxyprogesterone may also increase the risk of uterine or ovarian cancer in some women. Long-term treatment with estrogens and progestins (such as medroxyprogesterone) may also increase your risk of heart attack, blood clot, or stroke. Talk to your doctor about your specific risks and benefits of taking this medication, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Avoid smoking while you are taking medroxyprogesterone. Smoking greatly increases your risk of blood clots.

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