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Zinopril 20 Mg

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Indications:

Treatment of hypertension; treatment of heart failure not responding to diuretics and digitalis; treatment of acute MI within 24 h in hemodynamically stable patients. Unlabeled Uses Migraine prophylaxis.

Contraindications:

Hypersensitivity to ACE inhibitors; hereditary or idiopathic angioedema.

Adverse reactions:

Anaphylactoid reactions. Head and neck angioedema. Intetinal angioedema sometimes expressed as abdominal pain. Hypotension. Leukopenia/Neutropenia/Agranulocytosis. Hepatic failure. Fatal/Neonatal morbidity and mortality.

Interactions:

Antacids Lisinopril bioavailability may be decreased. Separate administration times by 1 to 2 h. Antidiabetic agents Risk of hypoglycemia may be increased. Capsaicin Cough may be exacerbated. Digoxin May increase or decrease plasma digoxin levels. Diuretics Excessive decrease in blood pressure may occur. Gold therapy (eg, aurothiomalate) Nitritoid reactions, including facial flushing, nausea, vomiting, and hypotension, may occur. Indomethacin, salicylates (eg, aspirin) Reduced hypotensive effects, especially in low-renin or volume-dependent hypertensive patients. Lithium Increased lithium levels and symptoms of lithium toxicity. NSAIDs Increased risk of renal function impairment. Phenothiazines May increase pharmacological effect of lisinopril. Potassium-sparing diuretics, potassium preparations May increase serum potassium levels. Laboratory Test Interactions False elevation of liver enzymes or serum bilirubin may occur.

Warnings:

should be given with caution in: Aortic stenosis/Hypertrophic cardiomyopathy. Impaired Renal function. Hyperkalaemia. Cough. Surgery and anaesthesia. Pregnancy categories C (first trimester) and D (second and third trimester) No data is available for the use under the age of 6 in children

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Consultants Corner

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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