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Goutnil

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Indications:

treats acute flares of Gouty Arthritis, acute gout and prevents the progression of the disease. Colchicine also decreases the attacks of Gout and arthritis. Colchicine can also relieve the pain and discomfort brought about by such diseases. It can also treat the inflammation of pseudo gout; Familial Mediterranean fever: amyloidosis and scleroderma; and other uncommon diseases.

Contraindications:

Hypersensitivity; blood dyscrasias, severe renal impairment, pregnancy, debilitated patients; SC/IM admin.

Adverse reactions:

Nausea, vomiting and abdominal pain; diarrhoea, GI haemorrhage, rashes, renal and hepatic damage in excessive doses. Rarely peripheral neuritis, myopathy, alopecia and with chronic therapy blood disorders like agranulocytosis, aplastic anaemia.

Interactions:

Reversible malabsorption of vitamin B12 may occur because of ileal mucosal function alteration. Response to CNS depressants and sympathomimetics may increase when used concurrently with colchicine. Increased risk of myopathy when used concurrently with simvastatin. Potentially Fatal: With ciclosporin, increased risk of nephrotoxicity and myotoxicity. Risk of colchicine toxicity when used with macrolides.

Warnings:

Elderly; GI disease. Cardiac, renal and hepatic impairment; prolonged therapy not recommended; lactation. Pregnancy: Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

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