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Luai Al Bakour
El Temamy Pharmacy
Akoni Hijyen Teknolojileri Sanayi ve Dış Ticaret LTD. ŞTİ
Britton Chance Center for Biomedical Photonics
Arabian Trade Center - ATC
Medical Facility (32206):
Legality International. (Pvt.) Ltd.
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Antihistamine and mucolytic.Loratadine, ambroxol Tablets is indicated for the symptomatic relief of allergic respiratory processes associated with nonproductive cough and mucus in the respiratory tract. It is also indicated for the treatment of patients with allergic bronchopulmonary process that is accompanied by increased mucus viscosity and adhesion, as is necessary to keep clear of secretions in the airways. Its main indications include allergic rhinitis associated with cough, bronchitis, bronchiectasis, sinusitis, pneumonia, bronchopneumonia, atelectasis by mucous plug, tracheotomy, and pre-and postoperative prophylactic agent, especially in elderly patients with suspected some allergic condition.
Loratadine, ambroxol Tablets is contraindicated in patients with hypersensitivity or idiosyncrasy to its components, peptic ulcer, children under 6 years.
The incidence of adverse reactions associated with each component of the formulation, loratadine and ambroxol is comparable to placebo. A recommended daily dose LARITOL * EX tablets no clinically significant sedative effects. The most commonly reported adverse effects include gastrointestinal disorders such as nausea, gastritis, constipation and diarrhea, dry mouth and dryness of the airways, increased salivation and nasal discharge, dysuria, fatigue, headache, drowsiness, dry mouth and allergy symptoms such as rashes. On rare occasions during the marketing of loratadine have been reported cases of alopecia, anaphylaxis, hepatic failure.
Loratadine: When administered concomitantly with alcohol, Loratadine has no potentiating effects as measured by psychomotor performance studies. It has been reported an increase in plasma concentrations of loratadine after administration of ketoconazole, erythromycin or cimetidine in controlled clinical studies, but there has been no clinically significant changes (including electrocardiographic). Caution should be exercised when co-administering Other drugs that inhibit the metabolic liver until they can make definitive interaction studies.
Patients with severe hepatic impairment should be given a lower dose initially, as these patients may have a slower clearance of loratadine, the recommended starting dose is 5 mg once daily or 10 mg on alternate days. Must be used with caution in patients with gastric ulcer. RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION Has not been established whether the administration of Loratadine, ambroxol can represent any change during pregnancy. Therefore, the drug should be used only if the potential benefit to the mother justifies the potential risk to the fetus. It has been established that loratadine is excreted in human milk, because of the risk potential of antihistamines for infants, particularly newborns and premature babies should decide about stopping breast-feeding or discontinuation of the drug.
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Yaser Habrawi , F.R.C.S.Ed
Dr. Samer Al-Jneidy
Dr. Tahsin Martini
Dr . Dirar Abboud
Dr. Hani Najjar
Dr. Faisal Dibsi
Dr. Talal Sabouni
Samir Moussa M.D.