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Indications:

Inflammatory diseases of the joints. Osteoarthritis. Pain following surgery. Sciatica.

Contraindications:

It is contra-indicated in the following groups of patients those allergic to lornoxicam, or any of its excipients

Adverse reactions:

General : Headache, dizziness, somnolence, changes in appetite, increased sweating, loss of weight, oedema, allergic reactions, debility, weight increase. Central nervous system (CNS): Depression, insomnia. Eyes : Conjunctivitis, vision disorders. Gastro-intestinal: Abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, flatulence, dysphagia, constipation, gastritis, dry mouth, stomatitis, gastro-esophageal reflux, peptic ulceration with or without bleeding, esophagitis, haemorrhoidal or rectal bleeding. Haematological : Anemia, ecchymosis, prolonged bleeding time, thrombocytopenia Liver: Increased transaminases. Musculo-skeletal: Cramps in leg, myalgia. Neurological : Migraine, paraesthesia, taste perversion, tinnitus and tremor. Respiratory : Dyspnoea, symptoms of irritation in upper respiratory tract. Skin: Allergic skin reactions such as dermatitis, flushing and pruritis, loss of hair. Urogenital : Micturition disorders. Vascular : Palpitations, tachycardia, changes in blood pressure.

Interactions:

Anticoagulants. Sulphonylureas. Diuretics/ACE inhibitors/Digoxin. Lithium. Methotrexate/Ciclosporin. Cimetidine.

Warnings:

In patients with the following disorders, Lornoxicam should only be administered after careful risk-benefit assessment (see also Special precautions): Gastro-intestinal ulceration and bleeding in medical history; previous cerebrovascular haemorrhage; SLE; ulcerative colitis; Crohnas disease; porphyria; haematopoietic disorders; patients with reduced cardiac function. When treating patients with mild to moderate cardiac failure, attention must be paid to the risk of fluid retention and decreased renal function. Liver diseases (e.g. liver cirrhosis).

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