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Voxamine

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Indications:

used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

Contraindications:

Anuria - renal shutdown may increase risk of systemic accumulation of diphenidol.

Adverse reactions:

In a small number of patients undergoing this therapy have been reported auditory and visual hallucinations, disorientation and mental confusion. Vontrol is a weak central anticholinergic and such reactions have been observed when central anticholinergic agents such as atropine and scopolamine, have been used in conjunction with this therapy. These reactions may occur within 3 days of starting treatment and disappear spontaneously when the drug is suspended. Therefore, should not be used in conjunction with such drugs nor in patients with hypersensitivity to them is known. The drug should be discontinued if such symptoms occur. Drowsiness may occur, overstimulation, depression, sleep disturbances, dry mouth, gastrointestinal irritation (nausea and dyspepsia) or blurred vision. Slight dizziness may occur rarely, rash, malaise, headache and heartburn or heartburn. There has been a mild jaundice whose relation to the use of Vontrol is doubtful. In a small number of patients have seen a slight and transient drop in blood pressure.

Interactions:

CNS depression–producing medications - concurrent use may potentiate the effects of either these medications or diphenidol; anticholinergics or other medications with anticholinergic activity - anticholinergic effects may be potentiated when these medications are used concurrently with diphenidol; apomorphine - prior ingestion of diphenidol may decrease the emetic response to apomorphine in the treatment of poisoning.

Warnings:

Vontrol antiemetic effect may mask signs of drug ingestion (eg.: Digital) or obscure the diagnosis of disorders such as intestinal obstruction or brain tumor. Although there have been reports of blood dyscrasia with Vontrol, patients should be observed regularly for whatever idiosyncratic reaction. Vontrol has a weak peripheral anticholinergic effect and should be used with caution in patients with glaucoma, obstructive lesions, gastrointestinal and genitourinary tract such as peptic ulcer, prostatic hypertrophy, pyloric and duodenal obstruction and organic cardio. Vontrol tablets containing FD /u0026 C Yellow No.5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. Pregnancy and Lactation: During pregnancy: Reproduction studies in animals conducted with Vontrol in rats and rabbits showed no evidence of harmful effects of drugs on the fetus. However, Vontrol should only be used in pregnant patients when the doctor finds that their use is essential to the welfare of the patient. In infancy: no suitable data available Vontrol use during breastfeeding, so it should not be used during this period.

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Consultants Corner

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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