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Digimerck

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Indications:

Cardiac arrhythmias, Heart failure

Contraindications:

Wolff-Parkinson-White syndrome; hypertrophic obstructive cardiomyopathy.

Adverse reactions:

Nausea, vomiting, anorexia, diarrhoea, abdominal pain, headache, facial pain, fatigue, weakness, dizziness, drowsiness, disorientation, mental confusion, bad dreams, delirium, acute psychoses, hallucinations, convulsions, blurred vision, color vision may be affected, gynecomastia, vasoconstriction, and transient hypotension (rapid IV inj), local irritation (SC/IM), hypersensitivity reactions, thrombocytopenia. Potentially Fatal: Heart failure, supraventricular or ventricular arrhythmias, conduction defects.

Interactions:

Thiazides, loop diuretics; corticosteroids; β2-agonists, amphotericin B; sodium polystyrene sulfonate; carbenoxolone; IV admin of calcium salts; quinidine; amiodarone; propafenone; other antiarrhythmics; β-blockers; calcium-channel blockers. Increased hepatic clearance by enzyme inducers e.g. rifampicin and aminoglutethimide. Potentially Fatal: Reduce dose of digitoxin when there is hypokalaemia, hypomagnesaemia, hypercalcaemia, hypoxia, or hypothyroidism.

Warnings:

CV disease; partial heart block, sinus node disorders, acute myocarditis, acute MI, advanced heart failure, severe pulmonary disease, thyroid dysfunction, hypokalaemia, hypomagnesaemia, hypercalcaemia, hypoxia, hypothyroidism, impaired renal function, elderly, premature infants. Maintain heart rate >60 beats/minute. withdraw 1-2 days before undergoing cardioversion. Not an appropriate form of therapy for any ventricular arrhythmia. Pregnancy. pregnancy: Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

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