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Espaven Alcalino

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Indications:

For the relief of hyperacidity and flatulence associated with heartburn, gastritis and acid indigestion, and as adjunctive treatment in peptic ulcers.

Contraindications:

Sensitivity to any of the ingredients; Impaired renal function.

Adverse reactions:

Gastrointestinal: Constipation; diarrhea; nausea; vomiting; intestinal obstruction.

Interactions:

Oral tetracyclines, digoxin, oral iron preparations, anticholinergic drugs, barbiturates, quinines, quinidine, warfarin, vitamins, H2-receptor antagonists, oral isoniazid, sucralfate, sodium fluoride, ketoconazole, phenytoin, phenothiazines and methenamine: Aluminium Mg.S may reduce the absorption of these agents.

Warnings:

Low-phosphate diets: Aluminium hydroxide in patients with low-phosphate diets may lead to phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia. Chronic renal failure: Osteomalacia, and also encephalopathy and dementia, have occurred in patients with chronic renal failure who received relatively high doses of aluminium hydroxide as a phosphate-binding agent. Hypermagnesemia has occurred after the excessive use of magnesium-containing antacids and especially in renal insufficiency. Symptoms may include flushing of the skin, thirst, hypotension due to peripheral vasodilatation, drowsiness, confusion, loss of tendon reflexes due to neuromuscular blockade, muscle weakness, respiratory depression, cardiac arrhythmias, coma, and cardiac arrest.

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