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Indications:

Ventricular and supraventricular disorders. Wolf- Parkinson-White syndrome. Angina pectoris.

Contraindications:

Severe bradycardia . Occlusive or impairment of atrioventricular conduction. Hypersenstivity to the drug. Severe Hypotension Respiratory system disorders.

Adverse reactions:

Few undesirable adverse effects associated with the use of Amiodarone HCl including severe bradycardia, conduction disturbances, severe hypotension. Amiodarone HCl is reported to reduce the peripheral transformation of (T4 ) to (T3), it can affect thyroid function and may induce hypo-or hyperthyroidism. Benign yellowish-brown corneal microdeposits may rarely occur, however other disorders include the occurance of corneal coloured haloes of light, peripheral neuropathy disorders, pulmonary and rarely neurological disorders have been reported in few rare cases. It has been suggested that Amiodarone HCl – induced phospholipidosis may explain some of its adverse effects, it also affects the hepatic enzymes.

Interactions:

Amiodarone HCl may alter the thyroid function tests. Amiodarone HCl increases the anticoagulant effects of warfarin. Amiodarone HCl increases the plasma concentration of digoxin and phenytoin. Phenytoin reduces the plasma concentration of Amiodarone HCl. Cimetidine increases the plasma concentration of Amiodarone HCl. Should be used with caution in patients under calcium channel-blockers treatment.

Warnings:

Severe electrolyte disturbances must be corrected before its administration. Should be avoided in patients hypersensitive to iodine or subjects with thyroid gland disorders. Amiodarone HCl should not be used in conjunction with sodium chloride solutions. Patients taking Amiodarone HCl should avoid exposure to sunlight. Not recommended in pregnancy and neonates. Nursing mothers should stop breast feeding when the administration of the drug is extremely needed.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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