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Luai Al Bakour
El Temamy Pharmacy
Akoni Hijyen Teknolojileri Sanayi ve Dış Ticaret LTD. ŞTİ
Britton Chance Center for Biomedical Photonics
Arabian Trade Center - ATC
Medical Facility (32206):
Legality International. (Pvt.) Ltd.
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Fusidic acid is active in vitro against Staphylococcus aureus, most coagulase-negative staphylococci, Corynebacterium species, most clostridium species. Fusidic acid has no useful activity against enterococci or most Gram-negative bacteria (except Neisseria, Moraxella, Legionella pneumophila and Bacteroides fragilis). Fusidic acid is active in vitro and clinically against Mycobacterium leprae but has only marginal activity against Mycobacterium tuberculosis. One important use of fusidic acid clinically is its activity against methicillin-resistant Staphylococcus aureus. Many strains of MRSA remain sensitive to fusidic acid, but because there is a low genetic barrier to drug resistance (a single point mutation is all that is required), fusidic acid must never be used on its own to treat serious MRSA infection and should be combined with another antimicrobial such as rifampicin. Fusidic acid is often found in topical skin and eye preparations (e.g., Fucibet), a use which has been contested.
Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.
synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.
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Yaser Habrawi , F.R.C.S.Ed
Dr . Dirar Abboud
Dr. Hani Najjar
Dr. Faisal Dibsi
Dr. Talal Sabouni
Dr. Tahsin Martini
Samir Moussa M.D.
Dr. Samer Al-Jneidy