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Indications:

treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes.

Contraindications:

Hypersensitivity to sympathomimetic amines; advanced arteriosclerosis; symptomatic CV disease; moderate to severe hypertension; hyperthyroidism; glaucoma; agitated states; history of drug abuse; during or within 14 days following the administration of an MAOI.

Adverse reactions:

Cardiovascular Regurgitant cardiac valvular disease; palpitation; tachycardia; hypertension. CNS Overstimulation; restlessness; dizziness; insomnia; euphoria; dysphoria; tremor; headache; psychotic episodes. Dermatologic Allergic urticaria. GI Dry mouth; unpleasant taste; diarrhea; constipation. Genitourinary Impotence; changes in libido. Respiratory Primary pulmonary hypertension.

Interactions:

Guanethidine May decrease hypotensive effect of guanethidine. MAOIs (eg, phenelzine); furazolidone May cause hypertensive crisis and intracranial hemorrhage. Selective serotonin reuptake inhibitors (eg, fluoxetine) Sympathomimetic effects of phentermine and risk of “serotonin syndrome” may be increased.

Warnings:

Pregnancy Category C . Lactation Undetermined. Children 8?mg dose Safety and efficacy not established in children younger than 12 yr of age. 16 mg dose Safety and efficacy not established in children 16 yr of age or younger. Special Risk Patients Use with caution in patients with glaucoma, hypertension, and diabetes mellitus. Drug dependence Psychological and physical dependence may occur with continued use; this class of drugs has been extensively abused. Tolerance Tolerance to the anorectic effect usually develops within a few weeks. Primary pulmonary hypertension Has been reported with concurrent use of phentermine and fenfluramine or dexfenfluramine. Valvular heart disease Serious regurgitant cardiac valvular disease has been reported with concurrent use of phentermine and fenfluramine or dexfenfluramine.

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