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Indications:

It is used for: Bacterial infections of the ear, nose and throat, eg otitis media, sinusitis. Bronchitis. Pneumonia. Bacterial infections of the urinary tract. Gynaecological infections, eg gonorrhoea. Bacterial infection of the blood (septicaemia or blood poisoning). Bacterial infections in the abdomen (peritonitis). Bacterial infections of the stomach and intestines. Bacterial infection of the heart valves and the lining surrounding the heart (bacterial endocarditis). Bacterial meningitis. Typhoid and paratyphoid fever.

Contraindications:

Ampicillin is contraindicated for patients known to have hypersensitivity to any of the penicillins.

Adverse reactions:

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Rash. Itching (pruritus). Diarrhoea. Nausea. Vomiting. Inflammation of the large intestine (colitis). Liver or kidney disorders. Blood disorders. The side effects listed above may not include all of the side effects reported by the drug’s manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Interactions:

Concurrent use Allopurinol with Ampicillin may significantly increase the possibility of skin rash, especially in hyperuricemic patients. Probenecid decreases the renal tubular secretion of Ampicillin. Concurrent use of Ampicillin and Probenecid may result in increased and prolonged blood levels of Ampicillin. , macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin in the treatment of meningitis or in other situations in which a rapid bactericidal effect is necessary. Ampicillin, reduced oral contraceptive effectiveness in women taking Ampicillin. Concurrent use Methotrexate with Ampicillin has resulted in decreased clearance of Methotrexate and in Methotrexate toxicity. Ampicillin may reduce the bioavailability Atenolol. Case reports indicated that beta blockers may potentiate anaphylactic reactions of penicillin.

Warnings:

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Ampicillin should be discontinued and appropriate therapy instituted. Ampiral Òin the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Ampicillin should only be used to treat bacterial infections. They don’t treat viral infections (e.g. the common cold). As with any potent drug, periodic assessment of renal, hepatic, and hematopoietic function should be made during prolonged therapy. Pregnancy: Studies in animals given doses several times the human dose have revealed no evidence of adverse effects in the fetus. Breast feeding: Ampicillin is secreted in human milk. Caution should be exercised when Ampicillin is administered to a nursing mother.

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SOLUTION FOR INJECTION

Dosage and Administration

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Consultants Corner

Dr . Dirar Abboud

Dr . Dirar Abboud Hepatologist – Gastroenterologist

Dr. Samer Al-Jneidy

Dr. Samer Al-Jneidy Pediatrician

Dr. Faisal Dibsi

Dr. Faisal Dibsi Specialist of Otolaryngology - Head and Neck Surgery

Dr. Tahsin Martini

Dr. Tahsin Martini Degree status: M.D. in Ophthalmology

Dr. Hani Najjar

Dr. Hani Najjar Pediatrics, Neurology

Samir Moussa M.D.

Samir Moussa M.D. ENT Specialist

Dr. Talal Sabouni

Dr. Talal Sabouni UROLOGY AND KIDNEY TRANSPLANT

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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