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Alsucral

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Indications:

Short-term treatment of duodenal ulcer; maintenance therapy of duodenal ulcer (tablets only). Unlabeled Uses Treatment of gastric ulcers; reflux and peptic esophagitis; treatment of NSAID- or aspirin-induced GI symptoms and mucosal damage; prevention of stress ulcers and GI bleeding in critically ill patients; treatment of oral and esophageal ulcers caused by radiation, chemotherapy, and sclerotherapy; treatment of oral ulcerations and dysphagia in patients with epidermolysis bullosa.

Contraindications:

Standard considerations.

Adverse reactions:

CNS Dizziness; insomnia; vertigo; headache. Dermatologic Rash; pruritus. GI Constipation (2%); diarrhea; nausea; vomiting; dry mouth; indigestion; flatulence. Miscellaneous Back pain.

Interactions:

Aluminum-containing antacids May increase total body burden of aluminum. Cimetidine, ciprofloxacin (and other quinolone antibiotics), diclofenac, digoxin, hydantoins (eg, phenytoin), ketoconazole, levothyroxine, penicillamine, quinidine, ranitidine, tetracycline, theophylline Oral absorption and pharmacologic action of these agents may be reduced if given with sucralfate. Administer 2 h apart from sucralfate.

Warnings:

Pregnancy Category B . Lactation Undetermined. Children Safety and efficacy not established. Chronic renal failure/dialysis Small amounts of aluminum may be absorbed from sucralfate, and concomitant use of other aluminum-containing products may increase total body burden of aluminum. Aluminum is not removed by dialysis and excretion through kidneys is impaired in patients with chronic renal failure. Aluminum accumulation and toxicity (eg, aluminum osteodystrophy, osteomalacia, encephalopathy) have occurred.

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