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Thromboreductin

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Indications:

Thromboreductin® is used to reduce the number of platelets (thrombocytes) in patients with essential thrombocythaemia. Large numbers of platelets can cause problems with blood circulation and clotting. Lowering the platelet count reduces the risk of serious problems.

Contraindications:

Do not take Thromboreductin® 0.5 mg in case of: - Hypersensitivity to Anagrelide or to any of the excipients of the medicinal product - Severe cardiovascular diseases - Severe renal insufficiency - Severe hepatic insufficiency Take special care with Thromboreductin® 0.5 mg - when you suffer from a cardiovascular diseases - when you suffer from renal or hepatic impairment

Adverse reactions:

If any of the side effects gets serious, or if you notice any side effect not listed in this leaflet, please tell your doctor or pharmacist. The possible side effects are ranked according to their frequency: very common (more than 1 out of 10 persons) common (more than 1 out of 100 persons and less than 1 out of 10 persons) uncommon (more than 1 out of 1,000 persons and less than 1 out of 100 persons) rare (more than 1 out of 10,000 persons and less than 1 out of 1,000 persons) very rare (less than 1 out of 10,000 persons) The following side effects may appear: Very common: Headache Common: Anaemia, ecchymosis, oedema, vertigo, paraesthesia, insomnia, palpitation, tachycardia, high blood pressure, epistaxis, nausea, diarrhoea, dyspepsia, eczema, backache, fatigue Uncommon: thrombocytopenia, bleeding, haematoma, weight gain, depression, nervousness, dry mouth, migraine, vision anomalia, conjunctivitis, tinnitus, cardiac insufficiency, arrhythmia, fast heart beat, syncope, dyspnoea, respiratory infection, vomiting, flatulence, obstipation, abdominal pain, alopecia, pruritus, myalgia, arthralgia, renal insufficiency, infection of the urinary tract, pain, weakness Rare: atrial fibrillation, angina pectoris, myocardial infarction, low blood pressure, pleura effusion, pneumonia, asthma, gastritis, anorexia, skin rash, nycturia, transaminase increase, influenza like symptoms, ague, malaise

Interactions:

The concomitant use of Thromboreductin® and acetylsalicylic acid (Aspirin®) may cause an elevated tendency for bleeding. In some patients the use of Thromboreductin may cause intestinal disturbance and thus compromise the absorption of oral contraceptives. Taking Thromboreductin® 0.5 mg capsules with food and drink Food delays the absorption of the active ingredient without effect on the efficacy of Thromboreductin®. Grapefruit juice may delay the degradation of the active ingredient Anagrelide hydrochloride.

Warnings:

Pregnancy and breast-feeding Thromboreductin® should not be taken during pregnancy. During therapy with Thromboreductin® adequate contraceptive measurements have to be applied. Breastfeeding is not allowed during therapy with Thromboreductin®. Driving and using machines: Patients suffering from dizziness after taking Thromboreductin® should not drive or use machines which require full concentration.

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