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Novo-prazin

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Indications:

Treatment of hypertension.

Contraindications:

Hypersensitivity to doxazosin, prazosin, or terazosin.

Adverse reactions:

Cardiovascular Palpitations; orthostatic hypotension; hypotension; tachycardia. CNS Depression; dizziness; nervousness; paresthesia; asthenia; drowsiness; headache. Dermatologic Pruritus; rash; sweating; alopecia; lichen planus. EENT Blurred vision; conjunctivitis; tinnitus; nasal congestion; epistaxis. GI Nausea; vomiting; dry mouth; diarrhea; constipation; abdominal discomfort or pain. Genitourinary Impotence; urinary frequency; incontinence; priapism. Respiratory Dyspnea. Miscellaneous Arthralgia; edema; fever.

Interactions:

Alcohol Increased risk of hypotension. Beta-blockers Enhanced acute orthostatic hypotensive reaction after first dose of prazosin. Verapamil Increased serum prazosin levels and increased sensitivity to orthostatic hypotension.

Warnings:

Pregnancy Category C . Lactation Excreted in breast milk. Children Safety and efficacy not established. Concomitant therapy When adding a diuretic or other antihypertensive agent, reduce dosage to 1 to 2 mg 3 times daily and then retitrate. First-dose effect May cause marked hypotension (especially orthostatic) and syncope at 30 min after first few doses, after reintroduction, with rapid increase (at least 2 mg) in dosing, or after addition of another antihypertensive. To avoid, initiate dosing with low dose (1 mg or up to 2 mg) and gradually increase after 2 wk. Lipids May decrease total cholesterol levels and LDLs and increase HDLs.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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