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Trifed Expectorant

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Indications:

Temporary relief of cough and upper respiratory tract symptoms, including nasal congestion, associated with allergy or common cold.

Contraindications:

this medicine is contraindicated in individuals who have previously exhibited intolerance to it or to pseudoephedrine or triprolidine. this medicine is contraindicated in patients who are taking or have taken monoamine oxidase inhibitors within the preceding two weeks. The concomitant use of pseudoephedrine and this type of product may occasionally cause a rise in blood pressure. this medicine is contraindicated in patients with severe hypertension or severe coronary artery disease. The antibacterial agent furazolidone, is known to cause a dose-related inhibition of monoamine oxidase. Although there are no reports of hypertensive crises caused by the concurrent administration of Multi-Action ACTIFED Tablets and furazolidone they should not be taken together.

Adverse reactions:

Central nervous system depression or excitation may occur, drowsiness being reported most frequently. Sleep disturbance and, rarely, hallucinations have been reported. Skin rashes, with or without irritation, tachycardia, dryness of mouth, nose and throat, have occasionally been reported. Urinary retention has been reported occasionally in men receiving pseudoephedrine; prostatic enlargement could have been an important predisposing factor.

Interactions:

Concomitant use of this medicine with sympathomimetic agents, such as decongestants, tricyclic antidepressants, appetite suppressants and amfetamine-like psychostimulants, or with monoamine oxidase inhibitors which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure. Because of its pseudoephedrine content, this medicine may partially reverse the hypotensive action of drugs which interfere with sympathetic activity including bretylium, betanidine, guanethidine, debrisoquine, methyldopa, alpha-and beta-adrenergic blocking agents.

Warnings:

this medicine may cause drowsiness and impair performance in tests of auditory vigilance. Patients should not drive or operate machinery until they have determined their own response. Although there are no objective data, users of this medicine should avoid the concomitant use of alcohol or other centrally acting sedatives. Although pseudoephedrine has virtually no pressor effect in normotensive patients, this medicine should be used with caution in patients taking anti-hypertensive agents, tricyclic antidepressants or other sympathomimetic agents, such as decongestants, appetite suppressants and amfetamine-like psychostimulants. The effects of a single dose of this medicine on the blood pressure of these patients should be observed before recommending repeated or unsupervised treatment. As with other sympathomimetic agents this medicine should be used with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement. There have been no specific studies of this medicine in patients with hepatic and/or renal dysfunction. Caution should be exercised in the presence of severe renal or hepatic impairment. There is insufficient information available to determine whether triprolidine or pseudoephedrine have mutagenic or carcinogenic potential. Systemic administration of pseudoephedrine in rats, up to 7 times the human daily dosage in females and 35 times the human daily dosage in males, did not impair fertility nor alter foetal morphological development and survival. No studies have been conducted in animals to determine if triprolidine has the potential to impair fertility. There is no information on the effects of this medicine on human fertility. The packs carry the following statements:- Store below 25oC Keep dry Protect from light Keep out of the reach of children Warnings, may cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink. The 12 tablet pack carries the additional statements:- If symptoms persist consult your doctor. Do not exceed the stated dose. As with all medicines if you are pregnant, or currently taking any other medicine, consult your doctor or pharmacist before taking this product.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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