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Fludil

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Indications:

Prophylaxis of classic (with aura) or common (without aura) migraine. Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system).

Contraindications:

Hypersensitivity to flunarizine. Contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson’s disease or other extrapyramidal disorders.

Adverse reactions:

Drowsiness and / or fatigue, as well as weight gain and / or increased appetite may occur. The following adverse experiences have been reported during chronic treatment with FLURAZINE-5: depression, of which female patients with a history of depressive illness may be particularly at risk; extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients seem particularly at risk. Infrequently reported adverse reactions are: heartburn; nausea; gastralgia; insomnia; anxiety; galactorrhoea; dry mouth; muscle ache; skin rash.

Interactions:

Galactorrhoea has been reported in few women on oral contraceptives within the first two months of treatment. Hepatic enzyme inducers such as carbamazepine and phenytoin may interact with flunarizine by increasing its metabolism. An increase in dosage of flunarizine may be required. Alcohol and CNS depressant enhancing the suppression effects of the product.

Warnings:

May lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. Patients should be cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. Not suited for aborting a migraine attack. The possible occurrence of an attack is therefore no reason to increase the dose . This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly. should therefore be used with caution in such patients.

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