Indications:

Replacement therapy in hypothyrodism Myxoedema Severe and chronic hypothyroidism T3 Supression test Simple goitre

Contraindications:

Recent MI or thyrotoxicosis; uncorrected adrenal insufficiency; artificial rewarming (IV).

Adverse reactions:

Hypersensitivity reactions, angina, CHF, fever, phlebitis, twitching, changes in BP. Potentially Fatal: Tachycardia, cardiac arrhythmias, cardiopulmonary arrest, MI

Interactions:

Reduced absorption with iron, colestyramine, colestipol, aluminium- and magnesium-containing antacids, calcium carbonate, simethicone, sucralfate. May alter requirements of antidiabetic drugs. Reduced efficacy of thyroid replacement therapy with imatinib. Reduced serum levels with amiodarone, carbamazepine, phenytoin, phenobarbital, rifampicin, oestrogens. Potentially Fatal: Increased therapeutic and toxic effects of liothyronine and TCAs. May change hypoprothrombinaemic response to warfarin and other oral anticoagulants (markedly increased response during replacement). Increased risk of significant hypertension and tachycardia with ketamine.

Warnings:

Angina, heart failure; DM; diabetes insipidus; elderly; long-standing hypothyroidism; adrenal insufficiency; myxoedema. Do not use for wt loss. Pregnancy

Form:

SOLUTION FOR INJECTION