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Zinopril

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Indications:

Hypertension: Lisinopril is indicated for the treatment of hypertension. It may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents. Heart Failure lisinopril is indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis. Acute Myocardial Infarction Lisinopril is indicated for the treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction, to improve survival. Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, aspirin and beta blockers.

Contraindications:

Lisopril is contra-indicated in patients who are hypersensitive to lisinopril and in patients with a history of angioneurotic oedema related to previous treatment with an angiotensin-converting enzyme inhibitor. As with other ACE inhibitors,lisinopril should be avoided in pregnancy.

Adverse reactions:

Side effects may include: Chest pain, cough, diarrhea, dizziness, headache, low blood pressure

Interactions:

Nonsteroidal anti-inflammatory drugs Lithium Potassium preparations Water pills that may or may not leave potassium in the body

Warnings:

Reduction of initial dose and careful monitoring is recommended with volume-depleted, congestive heart failure, ischemic heart and cerebrovascular insufficiency patients since symptomatic hypotension may occur. In some patients with bilateral renal artery stenosis or stenosis of the artery to solitary kidney some rise of serum creatinine and blood urea may occur which is transient and disappear by discontinuation of therapy. Aspirin & NSAID’s may diminish the antihypertensive effect of lisinopril. Lisinopril may potentiate the effects of lithium.

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