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Peptac-150mg

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Indications:

Treatment and maintenance therapy of duodenal ulcer; management of gastroesophageal reflux disease (GERD; including erosive or ulcerative disease); short-term treatment of benign gastric ulcer; treatment of pathologic hypersecretory conditions (Zollinger-Ellison); maintenance therapy for gastric ulcer patients at reduced dosage after healing of acute ulcers; treatment of endoscopically diagnosed erosive esophagitis; maintenance of healing of erosive esophagitis. OTC Treatment and prevention of heartburn.

Contraindications:

contraindicated for patients known to have hypersensitivity to the drug or any of the ingredients

Adverse reactions:

Cardiovascular AV block; bradycardia; cardiac arrhythmias; premature ventricular beats. CNS Agitation; confusion; depression; dizziness; fatigue; hallucinations; headache; insomnia; malaise; motor disturbances; somnolence; vertigo. Dermatologic Alopecia; erythema multiforme; rash; vasculitis. EENT Blurred vision. GI Abdominal discomfort; constipation; diarrhea; nausea; pancreatitis; vomiting. Hematologic Acquired immune hemolytic anemia; agranulocytosis; autoimmune hemolytic or aplastic anemia; granulocytopenia; leukopenia; pancytopenia; thrombocytopenia. Hepatic Cholestatic or hepatocellular effects. Musculoskeletal Arthralgias; myalgias. Miscellaneous Anaphylaxis; angioneurotic edema; hypersensitivity reactions.

Interactions:

Diazepam, midazolam, triazolam Pharmacologic effects may be increased or decreased because of decreased GI absorption by ranitidine. Staggering administration times may avoid this reaction. Ethanol May increase plasma ethanol levels. Glipizide Possible increased hypoglycemia effect. Ketoconazole May decrease effects of ketoconazole. Lidocaine May cause increased lidocaine levels. Warfarin Ranitidine may interfere with warfarin Cl. Hypoprothrombinemic effects may increase; may need adjustment.

Warnings:

Pregnancy Category B . Lactation Excreted in breast milk. Children Safety and efficacy of ranitidine have been established in children 1 mo to 16 yr of age for the treatment of duodenal and gastric ulcers, GERD and erosive esophagitis, and the maintenance of healed duodenal and gastric ulcer. Safety and efficacy have not been established for the treatment of pathological hypersecretory conditions or the maintenance of healing of erosive esophagitis in children or in neonates less than 1 mo of age. Elderly May have reduced renal function; therefore, decreased drug Cl may be more common. Hypersensitivity Rare cases of anaphylaxis have occurred as well as rare episodes of hypersensitivity. Renal Function Decreased Cl may occur; dosage reduction may be needed. Hemodialysis reduces level of ranitidine-dosage; timing must be adjusted so that scheduled dose coincides with end of hemodialysis. Hepatic Function Use drug with caution; decreased Cl may occur. Hepatocellular injury May occur, manifested as reversible hepatitis, hepatocellular or hepatocanalicular or mixed, with or without jaundice. Rapid IV administration May rarely result in bradycardia, tachycardia, or premature ventricular beats, usually in patients predisposed to cardiac rhythm disturbances.

Form:

COATED TABLET

Dosage and Administration

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