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Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis



Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis

Keith T. Chan, MD , Grace A. Tye, MD , Rita A. Popat, PhD , William T. Kuo, MD , Kamil Unver, MBiomedE , Nishita Kothary, MD , Daniel Y. Sze, MD, PhD , Lawrence V. Hofmann, MD

American Journal of Obstetrics and Gynecology,
205:6, July 11, 2011

Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis

Objective
The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk.

Study Design
This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors.

Results
DVT was associated with COC use (P = .022) and with increasing degrees of common iliac vein stenosis (P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase (P = .01).

Conclusion
Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications.







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Prepared by: Dr. Awss Zidan






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