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Antenatal depressive symptoms increase the likelihood of preterm birth

Antenatal depressive symptoms increase the likelihood of preterm birth

Heather Straub, Marci Adams, J. Jo Kim, Richard K. Silver

American Journal of Obstetrics & Gynecology ,,
10.1016, July 12, 2012

Antenatal depressive symptoms increase the likelihood of preterm birth

We evaluated the relationship between antenatal depressive symptoms and preterm birth.

Study design
Patients completed the Edinburgh Postnatal Depression Scale between 24-28 weeks of gestation. A score ≥12 (or thoughts of self-harm) indicated an at-risk woman. Symptomatic women were compared to risk-negative patients for relevant demography, historical variables, and pregnancy outcome.

After screening 14,175 women we found a screen positive rate of 9.1% (n = 1298). At-risk women had a significant increase in preterm birth at <37, <34, <32, and <28 weeks of gestation. Multivariable analysis adjusting for maternal age, race/ethnicity, prior preterm delivery, and insurance status revealed a persistent association between antenatal depressive symptoms and preterm birth (adjusted odds ratio, 1.3; 95% confidence interval, 1.09–1.35), which was also observed after multiple gestations were excluded from the analysis (odds ratio, 1.7; 95% confidence interval, 1.38–1.99).

In this large cohort of prenatally screened women, those with depressive symptoms had an increased likelihood of preterm birth.

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Prepared by: Laila Nour

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