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This medication is used to treat infections of the vagina caused by a mixture of certain bacteria and fungi. It contains two ingredients. The first ingredient, metronidazole, works by killing certain bacteria. The second ingredient, nystatin, works by killing certain fungi.


This medication should not be used by anyone who: is allergic to metronidazole, nystatin, or any other ingredients of this medication. is taking oral (by mouth) metronidazole and also has an active neurological disorder, a history of blood disorders, an underactive thyroid, or underactive adrenal glands.

Adverse reactions:

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. Less common: diarrhea dizziness or lightheadedness dryness of mouth headache feeling of a "furry" tongue loss of appetite metallic taste or other change in taste sensation nausea vomiting More common: itching in the vagina pain during sexual intercourse thick, white vaginal discharge with no odour or with a mild odour Less common: abdominal or stomach cramping or pain burning or irritation of penis of sexual partner burning during urination or need to urinate more often itching, stinging, or redness of the genital area Rare: burning in the vagina not present before use of this medication Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.


This medication may affect how the following work, may be affected by them, or together they may increase the risk of side effects: alcohol barbiturates (e.g., primidone, phenobarbital) disulfiram warfarin If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to: stop taking one of the medications, change one of the medications to another, change how you are taking one or both of the medications, or leave everything as is. An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than the ones listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.


Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Male partner: When there is evidence of infection in a male sexual partner, he should be treated at the same time with oral metronidazole (taken by mouth) to avoid re-infection. Side effects: It is possible (but much less likely) that side effects normally associated with the use of oral metronidazole may occur following the use of metronidazole used vaginally. Underclothing: To help the infection go away more quickly, wear cotton (instead of synthetic) underwear or pantyhose with cotton gussets. Pregnancy: This medication has not been studied for use by pregnant women. Talk with your doctor about the risks and benefits of using this medication while pregnant. Breast-feeding: Metronidazole passes into breast milk and may affect a nursing infant. Before breast-feeding your child while using this medication, speak to your doctor about the risks and benefits involved.



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