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Adjunctive treatment of tuberculosis; short-term management to eliminate meningococci from nasopharynx in Neisseria meningitidis carriers. - Unlabeled Uses: Treatment of infections caused by Staphylococcus aureus and Staphylococcus epidermidis ; treatment of gram-negative bacteremia in infancy; treatment of Legionella ; management of leprosy; prophylaxis of Haemophilus influenzae meningitis.


Hypersensitivity to any rifamycin.

Adverse reactions:

Cardiovascular: Hypotension; shock. CNS: Headache; drowsiness; fatigue; dizziness; inability to concentrate; mental confusion; generalized numbness; behavioral changes; myopathy. Dermatologic: Rash; pruritus; urticaria; pemphigoid reaction; flushing. EENT: Visual disturbances; exudative conjunctivitis. GI: Heartburn; epigastric distress; anorexia; nausea; vomiting; gas; cramps; diarrhea; sore mouth and tongue; pseudomembranous colitis; pancreatitis. Genitourinary: Hemoglobinuria; hematuria; renal insufficiency; acute renal failure. Hematologic: Eosinophilia; transient leukopenia; hemolytic anemia; decreased hemoglobin; hemolysis; thrombocytopenia. Hepatic: Asymptomatic elevations of liver enzymes and hepatitis. Respiratory: Shortness of breath; wheezing. Miscellaneous: Ataxia; muscular weakness; pain in extremities; osteomalacia; myopathy; menstrual disturbances; fever; elevations in BUN; elevated serum uric acid; possible immunosuppression; abnormal growth of lung tumors; reduced 25-hydroxycholecalciferol levels; edema of face and extremities; discoloration of body fluids.


Azole antifungal agents, benzodiazepines, beta-blockers, buspirone, chloramphenicol, clarithromycin, clozapine, oral contraceptives, corticosteroids, cyclosporine, delavirdine, digitoxin, disopyramide, doxycycline, erythromycin, estrogens, haloperidol, hydantoins, indinavir, losartan, methadone, mexiletine, morphine, nelfinavir, ondansetron, oral anticoagulants, quinidine, quinine, ritonavir, sulfonylureas, tacrolimus, tamoxifen, theophyllines, tocainide, toremifene, tricyclic antidepressants, troleandomycin, verapamil, zolpidem Therapeutic efficacy may be decreased because of liver enzyme-inducing properties of rifampin. Digoxin: May decrease digoxin serum concentrations. Enalapril: May significantly increase BP. Halothane: Hepatotoxicity and hepatic encephalopathy have been reported with coadministration. Isoniazid: May result in higher rate of hepatotoxicity. Ketoconazole: May cause treatment failure of either ketoconazole or rifampin. Probenecid: Elevates rifampin levels.


Pregnancy: Category C Lactation: Excreted in breast milk. Discontinue nursing or drug. Hepatic Function: Dosage adjustment is necessary. Body fluids: Medication may cause harmless red-orange discoloration of urine, feces, saliva, sputum, sweat, and tears. Soft contact lenses may be permanently stained.



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