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Antagon H2


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Management of duodenal ulcer; treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis; therapy for benign gastric ulcer; treatment of pathologic hypersecretory conditions; prevention of upper GI bleeding. Unlabeled Uses Prevention of aspiration pneumonia and stress ulcers; herpes virus infection; chronic idiopathic urticaria; anaphylaxis (relieves dermatologic symptoms only); dyspepsia; used before anesthesia to prevent aspiration pneumonitis; treatment of hyperparathyroidism and control of secondary hyperparathyroidism in chronic hemodialysis patient; treatment of chronic viral warts in children.


Hypersensitivity to cimetidine or other H 2 antagonists.

Adverse reactions:

Cardiovascular Cardiac arrhythmias. CNS Headache; somnolence; fatigue; dizziness; confusional states; hallucinations. Dermatologic Exfoliative dermatitis or erythroderma; alopecia; rash; erythema multiforme; epidermal necrolysis. GI Diarrhea. Genitourinary Impotence; loss of libido. Respiratory Bronchospasm. Miscellaneous Gynecomastia; hypersensitivity reactions; transient pain at injection site; reversible exacerbation of joint symptoms with pre-existing arthritis, including gouty arthritis


Antacids, anticholinergics, metoclopramide May decrease absorption of cimetidine. Benzodiazepines, caffeine, calcium channel blockers, carbamazepine, chloroquine, labetalol, lidocaine, metoprolol, metronidazole, moricizine, pentoxifylline, phenytoin, propranolol, quinidine, quinine, sulfonylureas, theophyllines, triamterene, tricyclic antidepressants, warfarin Cimetidine may reduce metabolism and increase serum concentration and pharmacologic/toxic effects of these drugs. Carmustine Bone marrow toxicity may be enhanced. Cigarette smoking Reversed cimetidine’s effects on suppression of nocturnal gastric secretion. Ferrous salts, indomethacin, fluconazole, ketoconazole, tetracyclines Cimetidine may decrease absorption of these drugs. Hydantoins Hydantoin levels may increase. Narcotic analgesics Toxic effects (eg, respiratory depression) may be increased. Procainamide Levels of procainamide and its active metabolite may increase. Tocainide Cimetidine may decrease the pharmacologic effects of tocainide.


Pregnancy Category B . Lactation Excreted in breast milk. Children Safety and efficacy not established. Elderly May have reduced renal function; decreased Cl may occur. Hypersensitivity Rare cases of anaphylaxis have occurred as well as rare episodes of hypersensitivity. Renal Function Decreased Cl may occur; reduced dosage may be needed. Hepatic Function Use caution; decreased Cl may occur. Gastric malignancy Symptomatic relief with cimetidine does not preclude gastric malignancy. Antiandrogenic effect Gynecomastia may occur, especially in patients treated for pathologic hypersecretory states. Rapid IV administration Has been followed by rare instances of cardiac arrhythmias and hypotension. Reversible CNS effects Mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation have occurred, predominantly in severely ill patients. Advanced age and pre-existing liver or renal disease appear to be contributing factors.



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