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Long term prevention of : Bronchial asthma(all forms, including Mixed) Allergic bronchitis Asthmatic symptoms associated with hay fever. It may take several weeks before the full therapeutic effect of ketotifen is achieved. Prevention and treatment of: Multisystemic allergies Allergic rhinitis Allergic dermatoses ketotifen is not effective in aborting established attacks of asthma. ymptomatic treatment of seasonal allergic conjunctivitis


Hypersensitivity to ketotifen.

Adverse reactions:

Sedation and in isolated cases, dryness of the mouth and slight dizziness may occur at the start of treatment but normally disappear quickly and spontaneously. Weight gain has occasionally been reported. Sedation rarely occurs in children and is less severe than in adults. Increased excitability and agitation have been reported in approximately 0.2% of patients, particularly in children.


A reversible fall in the thrombocyte count has been reported in a few cases in which ketotifen was being given concomitantly with an oral anti-diabetic agent. Thrombocyte count should therefore be performed in patients taking such drugs concomitantly. ketotifen may potentiate the effects of sedatives, hypnotics, antihistamines, and alcohol.


Anti-asthmatic drugs already in use should not be withdrawn abruptly at the start of ketotifen treatment. This applies particularly to systemic conticosteroids and ACTH, since there is risk of adrenal insufficiency in steroid dependent patients. In such cases, recovery of a normal pituitary-adrenal response to stress may take as long as one year. ketotifen may impair the reactions. Patients should therefore be warned to exercise caution when driving a vehicle, operating machinery, etc. PREGNANCY AND LACTATION Reproduction studies in animals do not suggest that the taking of ketotifen involves any risk of fetal damage, but this has not been confirmed by controlled trials in pregnant women. Its safety during pregnancy can not therefore be regarded as established, making very careful evaluation of the risk/benefit ratio is essential. It is not known whether ketotifen is excreted in breast milk.



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