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Treatment of hypertension in cases of therapeutic failure of monotherapy with low-dose diuretic.


The drug SHOULD NOT BE USED in the following cases: - Renal insufficiency (creatinine> 150 micromol / l or creatinine clearance <60 ml / min). The creatinine clearance is estimated by the Cockcroft: CrCl = (140-age) x weight / serum creatinine x 0.184 (with age expressed in years, weight in kg, serum creatinine in mol / l. The formula is valid for males, and must be corrected for Women by multiplying the result by 0.85. - Hyperkalemia - End-stage liver failure, - Hypersensitivity to sulfonamides, - Hypersensitivity to triamterene, - Associations with potassium salts or other diuretics (except in cases of hypokalemia) (see Section Interactions with other medicaments and other forms of interaction), - Breastfeeding. This medication is generally not recommended: - Cirrhotic patients when serum sodium is less than 125 mmol / l. Cirrhotic there is a risk of hyperkalemic acidosis. Some cases of macrocytic anemia or acute pancytopenia have been observed in these patients, - Patients may present acidosis.

Adverse reactions:

Side effects cannot be anticipated. If any occur or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Dyazide. Side effects may include: Abdominal pain, anemia, breathing difficulty, change in potassium level (causing symptoms such as numbness, tingling, muscle weakness, slow heart rate, shock), constipation, diabetes, diarrhea, dizziness, dizziness when standing up, dry mouth, fatigue, headache, hives, impotence, irregular heartbeat, kidney stones, muscle cramps, nausea, rash, sensitivity to light, strong allergic reaction (localized hives, itching, and swelling or, in severe cases, shock), vomiting, weakness, yellow eyes and skin


If Dyazide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Dyazide with the following: Blood-thinning medications such as warfarin Corticosteroids such as prednisone Drugs for diabetes such as glyburide Gout medications such as allopurinol Laxatives Lithium Methenamine Nonsteroidal anti-inflammatory drugs such as diflunisal and indomethacin Other drugs that minimize potassium loss or contain potassium Other high blood pressure medications such as prazosin Salt substitutes containing potassium Sodium polystyrene sulfonate


Before taking hydrochlorothiazide/triamterene, tell your doctor or pharmacist if you are allergic to it; or to sulfa medications; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (e.g., inability to make urine or anuria), high blood potassium levels (hyperkalemia), severe liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease (e.g., kidney stones), liver disease, untreated mineral imbalance (e.g., sodium, chloride), gout, lupus, metabolic imbalance (e.g., acidosis), folic acid deficiency. If you have diabetes, hydrochlorothiazide may worsen control of blood glucose levels. Monitor your blood glucose levels regularly and inform your doctor of the results. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors. Before having surgery, tell your doctor or dentist that you are taking this medication. This drug may make you dizzy or cause blurred vision; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Hydrochlorothiazide passes into breast milk. Consult your doctor before breast-feeding.



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