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Respiratory tract infections: bronchitits, pneumonia, sinusitis and otitis media. * Urinary tract infections * Gastrointestinal tract infections * Skin and soft tissue infections. * Gonorrhea. * Bone and joint infections. * Eye infections. * Prophylaxis in patients with reduced host defense & selective intestinal decontamination


Ciprofloxacin is contraindicated in cases of hypersensitivity to ciprofloxacin or any other drug of the same class, children and adolescents (below 18 years of age), pregnancy and nursing mothers.

Adverse reactions:

Ciprofloxacin is well tolerated, the most encountered side effects are: nausea, abdominal discomfort, diarrhea, vomiting headache, dizziness, fatigue, drowsiness & hypersensitivity reactions and rash, crystalluria, joint pain or stiffness, visual disturbances and photosensitivity.


* Simultaneous administration of Ciprofloxacin and iron, sucralfate, or antacids containing magnesium, aluminium, or calcium reduces the absorption of Ciprofloxacin. Ciprofloxacin should therefore be taken either 1-2 h before or at least 4 h after these products. This restriction does not apply antacids of the H2-receptor blocker type. * Simultaneous administration of Ciprofloxacin and theophylline can cause an undesirable rise in the serum theophylline concentration. This can lead to theophylline-determined side effects, If simultaneous use to the two products cannot be avoided, the serum concentrations of theophylline should be checked and the therophylline dose appropriately reduced. * It is known from animal studies that the combination of very high doses of quinolones (gyrase inhibitors) and certain anti-inflammatory drugs (nonsteroidal anti-inflammatory) can provoke convulsions. This is not, however, the case with drugs containing acetylsalicylic acid. * After simultaneous administration of Ciprofloxacin and cyclosporin a transient rise in serum creatinine has been observed in isolated cases. For this reason very frequent monitoring of the serum creatinine level (twice weekly) is necessary in these patients. * Simultaneous administration of Ciprofloxacin and warfarin can intensify the action of the warfarin. * After simultaneous administration of Ciprofloxacin and glibenclamide the action of the glibenclamide can be intensified in isolated cases (lowering of blood glucose, hypoglycaemia). * Probenecid influences the excretion of Ciprofloxacin in the urine. After simultaneous administration of Ciprofloxacin and probencid, the concentration of Ciprofloxacin in the blood (serum) rises. * Metoclopramide reduces the uptake to Ciprofloxacin into circulation, leading to maximum concentrations in the blood (serum) within a short time. No effect on availability in the human body (bioavailability) has been established.


As with other flouroquinolones, the dose of ciprofloxacin should be reduced to 100-200 mg daily in renally impaired patients (creatinine clearance below 20 ml/min). In patients with epilepsy or central nervous system damage, risk-benefits consideration should be measured carefully. Excessive exposure to sunlight should be avoided during treatment with ciprofloxacin. Adequate fluid intake should be maintained to avoid risk of crystalluria. Caution should be taken when operating machinery or activities requiring mental awareness.


Film-coated tablets

Dosage and Administration

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Dr. Samer Al-Jneidy

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Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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