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for the treatment of the following skin infections where co-existing symptoms of inflammation, e.g. itching, require rapid relief: a) All dermatomycoses due to dermatophytes (e.g. Trichophyton species), moulds and other fungi. b) All dermatomycoses due to yeasts (Candida species). c) Skin diseases showing secondary infection with these fungi. d) The treatment of nappy rash where infection due to Candida albicans is present. Candidal vulvitis, candidal balanitis and candidal intertrigo. Clotrimazole is a broad spectrum antifungal. It also exhibits activity against Trichomonas, staphylococci, streptococci and Bacteroides. It has no effect on lactobacilli.


Hypersensitivity to Clotrimazole, hydrocortisone or any of the excipients in this product. The following contra-indications apply to the hydrocortisone component: any untreated bacterial skin diseases, chicken pox, vaccination reactions, perioral dermatitis, viral skin diseases (e.g. herpes simplex, rosacea, shingles), use on broken skin, acne.

Adverse reactions:

Rarely, patients may experience local mild burning or irritation immediately after applying the cream. Very rarely, patients may find this irritation intolerable and stop treatment. Hypersensitivity reactions may occur. After use on large areas (more than 10% of the body surface) and/or after long-term use (longer than 2-4 weeks) or use under occlusive dressings, local skin alterations such as skin atrophy, teleangiectasias, hypertrichosis, striations, hypopigmentation, secondary infection and acneiform symptoms may occur.


Laboratory tests have suggested that, when used together, this product may cause damage to latex contraceptives. Consequently, the effectiveness of such contraceptives may be reduced. To date this has not been reflected in clinical practice.


The cream contains cetyl alcohol and stearyl alcohol, which may cause local skin reaction (e.g. contact dermatitis)Clotrimazole has not been associated with teratogenic effects but following oral administration of high doses to rats, there was evidence of fetotoxicity. The relevance of this effect to topical application in humans is not known. However, clotrimazole has been used in pregnant patients for over a decade without attributable effects. It is therefore recommended that clotrimazole should be used in pregnancy only when considered necessary by the clinician.



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