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Zanaflex

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Indications:

It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system.

Contraindications:

Increases in liver enzymes and rarely acute hepatitis have been associated with tizanidine and it is contra – indicated in patients with severe hepatic dysfunction.

Adverse reactions:

feeling light-headed, fainting, slow heart rate; hallucinations, confusion, unusual thoughts or behavior; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or burning or pain when you urinate. Less serious tizanidine side effects may be more likely to occur, such as: drowsiness or dizziness; feeling anxious or nervous; numbness or tingling; stomach pain, diarrhea, constipation, vomiting; fever; dry mouth; muscle weakness, back pain; increased muscle tone or spasms; or sweating or skin rash.

Interactions:

Concomitant use of tizanidine and moderate or potent CYP1A2 inhibitors is contraindicated. Concomitant use of tizanidine with fluvoxamine, a potent CYP1A2 inhibitor in man, resulted in a 33-fold increase in the tizanidine AUC (plasma drug concentration-time curve) by fluvoxamine.

Warnings:

This medicine may cause drowsiness. If affected do not drive or operate machinery. Your liver function should be monitored while you are taking this medicine. Symptoms that may suggest a liver problem include persistent nausea and vomiting, abdominal pain, or the development of jaundice (a yellow colouring to the skin and the whites of the eyes). Consult your doctor if you experience any of these symptoms. Use with caution in Decreased kidney function. Elderly people.

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