Home
My Account
About Us
Forum
Contact us
الواجهة العربية
epharmaweb.com
Medical News Medical News
Aricles Articles
Events Events
Guidelines Guidelines
Videos Library Videos Library
Diseases Diseases
Follow us : facebook twitter Digg Linkedin Boxiz
Newsletter

Please select the categories you are intersted in:
News Articles Guidelines Events Videos Journals' abstracts

Latest Subscribers
Advanced Search »



Actos

Main

You must sign in to use this servcie


Feedback - Please use the form below to send your query or comment

You must sign in to use this servcie

Username:
Password:

Info

Indications:

Type 2 diabetes, as monotherapy or as an adjunct to diet and exercise; also may be used in conjunction with a sulfonylurea, metformin, or insulin when diet, exercise, and a single agent alone does not result in adequate glycemic control in patients with type 2 diabetes mellitus.

Contraindications:

Established New York Heart Association class III or IV heart failure; hypersensitivity to any component of the product.

Adverse reactions:

Cardiovascular CHF. CNS Headache (9%). EENT Pharyngitis (5%); macular edema (postmarketing). GI Tooth disorders (5%). Hepatic Elevated ALT. Hematologic Anemia (less than 2%); decrease in hemoglobin and hematocrit. Lab Tests Decreased hemoglobin and hematocrit levels, elevated ALT, elevated CPK levels. Metabolic-Nutritional Hypoglycemia. Musculoskeletal Bone fractures, myalgia (5%). Respiratory Upper respiratory tract infection (13%); sinusitis (6%). Miscellaneous Edema (5%).

Interactions:

Contraceptives, oral Oral contraceptives may decrease both hormone components about 30%, potentially reducing contraceptive effectiveness. CYP2C8 enzyme inhibitors (eg, azole antifungal agents [eg, ketoconazole], fluvoxamine, gemfibrozil, trimethoprim) Pioglitazone plasma levels may be elevated, increasing the pharmacologic effects and adverse reactions. CYP2C8 inducers (eg, rifampin) Pioglitazone plasma concentrations may be reduced, decreasing the efficacy. Midazolam Plasma concentrations may be reduced by pioglitazone, decreasing the efficacy.

Warnings:

Warnings Pioglitazone can cause or exacerbate CHF in some patients. Consider discontinuing or reducing the dose if symptoms of heart failure occur. Treatment of patients with symptomatic heart failure is not recommended. Monitor After starting treatment or increasing the dose, carefully observe patients for signs and symptoms of heart failure (including excessive, rapid weight gain; dyspnea; and/or edema). Monitor liver enzymes prior to the start of therapy and periodically thereafter. Fasting blood glucose and hemoglobin A 1c (HbA 1c ) measurements should be performed periodically to monitor glycemic control and therapeutic response. Pregnancy Category C . Lactation Undetermined. Children Safety and efficacy not established. Hepatic Function Use with caution. Do not initiate therapy in patients with clinical evidence of active liver disease or baseline ALT more than 2.5 × ULN. Discontinue therapy if ALT increases to more than 3 × ULN and persists. Related drugs have reported rare hepatotoxicity. Bone Fractures Increased incidence of bone fractures noted in women but not men. Diabetic Ketoacidosis Not recommended. Edema Use caution; can cause fluid retention. Hematologic Decreases in Hgb and Hct (2% to 4%) have been reported and may be related to increases in plasma volume associated with pioglitazone therapy. Hyperglycemia May increase the risk of hypoglycemia when used in combination with other hypoglycemic agents; may need dose reduction of concomitant agents. Ovulation May result in ovulation in premenopausal anovulatory women; recommend contraception. Type 1 diabetes Not recommended. Weight gain Dose-related weight gain has been seen alone and in combination with other hypoglycemic agents.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

You must sign in to use this servcie

Technical Description

You must sign in to use this servcie






Forgot your password


sign up

Consultants Corner

Dr . Dirar Abboud

Dr . Dirar Abboud Hepatologist – Gastroenterologist

Dr. Faisal Dibsi

Dr. Faisal Dibsi Specialist of Otolaryngology - Head and Neck Surgery

Dr. Samer Al-Jneidy

Dr. Samer Al-Jneidy Pediatrician

Dr. Tahsin Martini

Dr. Tahsin Martini Degree status: M.D. in Ophthalmology

Dr. Hani Najjar

Dr. Hani Najjar Pediatrics, Neurology

Dr. Talal Sabouni

Dr. Talal Sabouni UROLOGY AND KIDNEY TRANSPLANT

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

Samir Moussa M.D.

Samir Moussa M.D. ENT Specialist
Poll

Which of the following you are mostly interested in?

Cancer Research
Mental Health
Heart Disease & Diabetes
Sexual Health
Obesity and Healthy Diets
Mother & Child Health

Disclaimer : This site does not endorse or recommend any medical treatment, pharmaceuticals or brand names. More Details