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this drug eases redness, irritation, and swelling due to inflammation of the eye.


You should not use this medication if you are allergic to prednisolone or other steroids, or if you have certain types of infection (viral, fungal, or bacterial) that can affect your eyes. If you have any of these other conditions, you may need a dose adjustment or special tests to safely use prednisolone ophthalmic: glaucoma; recent cataract surgery; or herpes simplex

Adverse reactions:

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects: pain behind your eyes, sudden vision changes, severe headache; sudden eye irritation; blurred vision, tunnel vision, eye pain, or seeing halos around lights; or signs of new eye infection, such as swelling, draining, or crusting of your eyes. Less serious side effects may include: temporary cloudy vision; increased sensitivity to light; or mild stinging, burning, itching, or irritation in your eyes


Aminoglutethimide May lead to loss of prednisolone-induced adrenal suppression. Amphotericin B Coadministration may be followed by cardiac enlargement and CHF. Anticholinesterase agents Coadministration may produce severe weakness in patients with myasthenia gravis. If possible, withdraw anticholinesterase agent 24 h prior to starting prednisolone. Antidiabetic agents Because prednisolone may increase blood glucose concentrations, dose adjustments of antidiabetic agents may be required. Aspirin and other salicylates, NSAIDs Risk of GI bleeding may be increased. Salicylate clearance may be increased. CYP3A4 inducers (eg, barbiturates, carbamazepine, phenytoin, rifampin) Prednisolone metabolism may be increased, reducing prednisolone plasma levels and necessitating an increase in dosage. CYP3A4 inhibitors (eg, estrogens [eg, hormonal contraceptives], ketoconazole, macrolide antibiotics [eg, erythromycin]) Prednisolone metabolism may be decreased, increasing prednisolone plasma levels and increasing the risk of adverse reactions. Cholestyramine Prednisolone clearance may be increased, reducing plasma levels and decreasing the efficacy. Cyclosporine Increased activity of cyclosporine and prednisolone may occur. Convulsions have been reported with coadministration of corticosteroids and cyclosporine. Digitalis glycosides Because of possible hypokalemia, the risk of arrhythmias may be increased. Isoniazid Isoniazid serum levels may be reduced, decreasing the efficacy. Potassium-depleting agents (eg, amphotericin B, diuretics) Risk of hypokalemia may be increased. Toxoids and live or inactivated vaccines Because of inhibition of antibody response, patients on prolonged prednisolone therapy may exhibit a diminished response to toxoids and live or inactivated vaccines. Replication of some organisms contained in live attenuated vaccines may be potentiated. Warfarin Because data are conflicting, monitor coagulation indices frequently.


Do not wear any contact lens that has not been approved by your doctor. Do not use prednisolone ophthalmic while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using prednisolone ophthalmic before putting your contact lenses in. Do not use any other eye medications unless your doctor has prescribed them. Prednisolone ophthalmic can cause side effects that may impair your vision. Be careful if you drive or do anything that requires you to see clearly.



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