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L-thyrox

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Indications:

Replacement therapy in the treatment of hypothyroidism . Suppress the secretion of TSH in condition such as diffuse non–toxic goitre and Hashimoto’s thyroiditis and thyroid carcinoma .

Contraindications:

Acute myocardial infarction and thyrotoxicosis uncomplicated by hypothyroidism . Hypersensitivity to active or extraneous constituents.

Adverse reactions:

The adverse effects are generally associated with excessive dosage and correspond to symptoms of hypothyroidism . Tachycardia , palpitations , cardiac arrhythmias , aginal pain , headache , nervousness , insominia , tremors , muscle weakness and cramps , heat intolerance , sweating , flushing , fever , weight loss , menstrual irregulavities , diarrhoea and vomiting.

Interactions:

Antiarrhythmics ( Amiodarone ) Antibacterials ( Enzyme induction by rifampicin ) Anticoagulants Antidepressants Antidiabetics Antiepileptics Antimalarials Antivirals Beta Blockers Cardiac glycosides Gastrointestinal drugs General anaesthetics Iron salts NSAIDs Sex hormones.

Warnings:

Obesity , infertility , cardiovascular disease , endocrine disorders , Morphologic hypogonadism and nephrosis , Myxedema . Abuse , Arenocortical insufficiency , Myasthenia .

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