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Too Much of an Antibody Molecule Increase Chances of Mortality


Too Much of an Antibody Molecule Increase Chances of Mortality

A new study at Mayo Clinic identified an immune system deficiency whose presence means a person could be four times more likely to die than a person without it.

The study, published in the June issue of May Clinic Proceedings, explains that this glitch involves an antibody molecule called free light chain. When the immune system produces too much of this molecule, chances of dying due to life-threatening illness such as cancer, diabetes and cardiac and respiratory disease increase.

The study suggests that high levels of free light chains are markers of increased immune system response to infection, inflammation or some other serious disorders, says lead researcher Vincent Rajkumar, M.D., a Mayo Clinic hematologist.

Researchers examined blood samples of nearly 16,000 thousand people who were at least 50 years old. They found that 10% of the samples had more free light chains than usual. These 10% were 4 times more likely to die than normal people.

Depending on these results, scientists linked increasing levels of free light chains to an increased risk of mortality in patients with plasma disorders, such as myeloma and other blood cancers. This study is the first to associate death with high levels of free light chains.

However, Dr. Rajkumar cautions against administering this test with the intent of gauging one's risk of death.

"We do not recommend this test as a screening test, because it will only cause alarm," Dr. Rajkumar says. "We do not know why this marker is associated with higher rates of death. We do not have a way of turning things around. Therefore, I would urge caution in using this test until we figure out what to do about it and what these results mean."


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Prepared by: Abdullatief Janat


Source :

ePharmaNews






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