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Aspirin Can Decrease Risk of Postoperative Complications

Aspirin Can Decrease Risk of Postoperative Complications

(epharmanews)- Since several studies have proved that aspirin was as effective in treating heart failure as warfarin, researchers conducted new studies to find more benefits for aspirin and so they found that aspirin plays a major role in preventing postoperative symptoms in patients who had a cardiac surgery.

Researchers from Thomas Jefferson University and the University of California evaluated the effects of preoperative aspiring on 4256 patients who had a heart surgery – mostly coronary artery bypass graft or valve surgery -at Thomas Jefferson University Hospital and UC Davis Medical Center between 2001 and 2009.

Among 2,868 patients who met the inclusion criteria, 1,923 were taking aspirin (within about 81 to 325 mg daily) at least once within five days preceding their surgery versus 945 not taking aspirin (non-aspirin therapy).

The result of this study, published in Annals of Surgery, suggest that heart surgery patients who had preoperative aspirin had lower postoperative (within 30 days after surgery) death rates, postoperative kidney failure and average time spent in the intensive care unit,  in comparison with those who did not take aspirin.

Researchers think that these results are very important because main postoperative complications were still high despite the significant advance in heart surgeries.

Dr. Jianzhong Sun, an anesthesiologist at Thomas Jefferson University and lead author of the study says: “Therapies targeted to prevent or reduce major complications associated with cardiac surgery have been few and ineffective so far,”

“These complications are significant and costly both for the public health and the quality of patient life.”

Adds Dr. Zvi Grunwald, chairman of Anesthesiology at Jefferson, “While we are excited that the study clearly showed that preoperative use of aspirin significantly reduced major complications and mortality in patients undergoing cardiac surgery, we do urge further study before recommending aspirin for cardiac surgery patients prior to surgery.”

“We know that aspirin can be lifesaving for patients who have experienced heart attacks,” said Dr. Nilas Young, chief of cardiothoracic surgery at UC Davis and a study co-author. “Now we know that this simple intervention can do the same for patients who undergo certain coronary surgeries. This outcome could lead to new preoperative treatment standards in cardiac medicine.”

“Overall, the outcome benefits provided by preoperative aspirin therapy may override its possible risk of excess bleeding in patients undergoing cardiac surgery. Nonetheless, further studies are certaianly needed to examine this potential side effect carefully,” Dr. Sun and colleagues write.

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Prepared by: Nessrin Biram

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