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Increased Risk of Aneurysm Tied to Early Menopause


Increased Risk of Aneurysm Tied to Early Menopause

(epharmanews)- A woman that experiences menopause at a younger age is at a greater risk of having a brain (cerebral) aneurysm, suggests research published online first in the Journal of NeuroInterventional Surgery.

A cerebral aneurysm refers to an abnormal bulging of one of the arteries in the brain, which is often only discovered when it ruptures, causing a potentially fatal or disabling bleed. Fluctuations in the female hormone estrogen have been implicated in the development of aneurysms, the incidence of which, along with cardiovascular disease, rises sharply after menopause, which makes women at more likely to develop cerebral aneurysms than men.

US researchers say monitoring women at risk and giving them hormone replacement therapy (HRT) may reduce the danger.

Early menopause occurs before 40, according to researchers from Mount Rush University Medical Center, Illinois.

The researchers, who are the authors of this study, based their finding on 76 postmenopausal women who had suffered a cerebral aneurysm and compared them with 532 postmenopausal women who had not had an aneurysm.

The average age at which women in both groups had started the menopause was similar, and analysis of the results showed that later menopause and use of HRT protected against the risk of a cerebral aneurysm, lessening the risk by 21% and 77%, respectively.

"Loss of estrogen earlier in a woman's life may contribute to the [development] of cerebral aneurysm," conclude the authors, adding that HRT may protect against this. And they suggest: "These data may identify a risk factor for [the development of this condition] and also a potential target for future therapies."


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Prepared by: Hasan Zaytoon


Source :

ePharmaNews






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