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New Transdermal Gel Found Successful at Reducing Sperm Count, Study


New Transdermal Gel Found Successful at Reducing Sperm Count, Study

(epharmanews)- A new study has uncovered a new contraceptive; a male hormonal gel that can reduce sperm production. The findings of this study were presented last Sunday at The Endocrine Society’s 94th Annual Meeting in Houston.

The study suggests that this gel was very effective in reducing chances of pregnancy. Very low sperm counts resulted for about 89 percent of men using a new combination of hormones, the authors reported. They combined a transdermal (skin) gel containing the male hormone testosterone and a gel containing a new synthetic progestin called Nestorone.

“This is the first time that testosterone and Nestorone have been applied to the skin together to deliver adequate amounts of hormones that suppress sperm production,” said principal investigator Christine Wang, MD, professor, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). “Men can use transdermal gels at home—unlike the usual injections and implants, which must be given in a health care provider’s office.”

Earlier studies have tested the effectiveness of combining testosterone and progestin used contraceptive pills. However, this is the first time these two hormones are tested as a transdermal (skin) gel.

Unlike other progestins studied as male contraceptives, Nestorone has no androgenic (male hormone) activity, Wang said. Androgenic activity may cause side effects such as acne and changes in good and bad cholesterol.

This preliminary study involved 99 healthy men. Some of them used the combination gel for 20 weeks while others used a gel made testosterone plus placebo. Researchers found that Only 23 percent of men who received testosterone alone obtained a sperm concentration less than 1 million sperm per milliliter, “a level that is compatible with very low pregnancy rates,” Wang said. For the testosterone-progestin combinations, sperm counts reached that level in 88 to 89 percent of men, depending on the progestin dose.

In addition, complete absence of sperm occurred in significantly more men receiving combined testosterone and progestin than testosterone alone: 78 and 69 percent (8 and 12 mg of progestin, respectively) versus 23 percent for testosterone only.

“The combination of testosterone with Nestorone had few adverse effects,” Wang said. “It warrants further study as a male contraceptive.”


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Prepared by: Basel AlJunaidy


Source :

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