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New Vaccine Tested on Mice can Prevent Nicotine Addiction


New Vaccine Tested on Mice can Prevent Nicotine Addiction

(epharmanews) - Researchers from the Weill Cornell Medical College have developed vaccine that was successful at treating mice from nicotine addiction.

The researchers wrote in the journal Science Translational Medicine a description of how a single dose of their innovative vaccine protects against nicotine addiction for as long as they lived. The vaccine is designed to use animal’s lifer as a factory to continuously produce antibodies that gobble up nicotine the moment it enters the bloodstream, preventing the chemical from reaching the brain and even the heart.

Lead researcher Dr. Ronald G. Crystal, chairman and professor of Genetic Medicine at Weill Cornell Medical College, said: “As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect,”

"Our vaccine allows the body to make its own monoclonal antibodies against nicotine, and in that way, develop a workable immunity," Dr. Crystal adds.

Earlier attempts to develop a nicotine vaccine failed because they all directly deliver nicotine antibodies which only last for a few weeks and need expensive, repeated injections, says Dr. Crystal.

The researchers are preparing to test the novel nicotine vaccine in rats and then in primates -- steps needed before it can be tested ultimately in humans. Dr. Crystal says that, if successful, such a vaccine would best be used in smokers who are committed to quitting. "They will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit," he says.

"While we have only tested mice to date, we are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches," he says. Studies show that between 70 and 80 percent of smokers who try to quit light up again within six months, Dr. Crystal adds.

"Smoking affects a huge number of people worldwide, and there are many people who would like to quit, but need effective help," he concluded. "This novel vaccine may offer a much-needed solution."


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Prepared by: Basel AlJunaidy


Source :

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