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Pregnant Women Who Take Antipsychotics are More Likely to Develop Gestational Diabetes


Pregnant Women Who Take Antipsychotics are More Likely to Develop Gestational Diabetes

(epharmanews) – Women who take certain antipsychotics when they are pregnant have and increased risk of developing gestational diabetes, which appear during pregnancy.

Gestational diabetes involves high blood sugar that starts or is first diagnosed during pregnancy. It can pose a serious threat to both the mother and the baby. The study is published in Archives of General Psychiatry, and it focused on drugs that are used to treat severe mental illnesses such as schizophrenia and bipolar disorder.

Researchers from Sweden proved these results after looking at the medical records for hundreds of thousands of women who gave birth between July 2005 and December 2009. They found that diabetes was more than twice as common in women who took antipsychotics during pregnancy. However, the study did not prove the antipsychotics directly increased the risk of gestational diabetes.

"Maternal use of antipsychotics during pregnancy ... is associated with an increased risk of gestational diabetes," the authors wrote. "Pregnant women treated with antipsychotics should be closely monitored for gestational diabetes and deviating fetal growth."

"This study and others recently have suggested that the use of antipsychotics during pregnancy is not as free of risk as traditionally thought," said Dr. Bryan Bruno, acting chairman of the department of psychiatry at Lenox Hill Hospital in New York City.

"The peak age of onset of schizophrenia in women is 25 to 35 years old, which are also the peak childbearing years," he added. "Women with psychotic illnesses are likely to have more unplanned pregnancies than women without a psychotic illness."

Bruno agrees that there is a lack of information about the potential association between these drugs and gestational diabetes.

"With limited research data on the impact of newer atypical antipsychotics during pregnancy, pregnant women with bipolar disorder or schizophrenia may be better off with the older antipsychotics," he added. He said the reproductive-safety data on older antipsychotics is more robust and reassuring than it is for newer drugs.


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Prepared by: Hasan Zaytoon


Source :

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